Multiomics-Based Signaling Pathway Network Alterations in Human Non-functional Pituitary Adenomas

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Exploration of Molecular Network Variations in Different Subtypes of Human Non-functional Pituitary Adenomas

1 Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, China, 2 Hunan Engineering Laboratory for Structural Biology and Drug Design, Xiangya Hospital, Central South University, Changsha, China, 3 State Local Joint Engineering Laboratory for Anticancer Drugs, Xiangya Hospital, Central South University, Changsha, China, 4 The Sta...

متن کامل

MicroRNAs in Human Pituitary Adenomas

MicroRNAs (miRNAs) are a class of recently identified noncoding RNAs that regulate gene expression at posttranscriptional level. Due to the large number of genes regulated by miRNAs, miRNAs play important roles in many cellular processes. Emerging evidence indicates that miRNAs are dysregulated in pituitary adenomas, a class of intracranial neoplasms which account for 10-15% of diagnosed brain ...

متن کامل

Analysis of Nitroproteome in Human Pituitary Adenomas

Protein tyrosine nitration is an important reactive oxygen species/reactive nitrogen species (ROS/RNS)-related modification that is derived from the main in vivo peroxynitrite pathway and the secondary myeloperoxidase reaction pathway (Scaloni, 2006, Khan et al., 1998, Zhan & Desiderio, 2009a, 2009b, and 2009c, Dalle-Donne et al., 2005, Zhan, Wang, & Desiderio, 2013). Tyrosine nitration adds an...

متن کامل

Human kallikrein 10 in surgically removed human pituitary adenomas.

OBJECTIVE Human kallikrein-like peptidase 10 (KLK10), a serine protease, plays an important role in the regulation of cell proliferation and tumor growth. In this work, we investigated KLK10 immunoexpression in various types of surgically removed human pituitary tumors. DESIGN Specimens were fixed in formalin and embedded in paraffin. Immunostaining was performed by the streptavidin-biotin-pe...

متن کامل

Microscopic Transsphenoidal Surgery for Pituitary Adenomas in Children and Adolescents

Background & Aim: We described the presentation, management and subsequent treatment outcomes of children and adolescents diagnosed with a pituitary adenoma in a joint neuroendocrine setting followed up by a single service as well as assessing long-term outcomes in terms of endocrine status and neurology symptoms. Methods & Materials/Patients: A total of 21 participants with histologically v...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Frontiers in Endocrinology

سال: 2019

ISSN: 1664-2392

DOI: 10.3389/fendo.2019.00835